a tool for identifying drug-targetable redox-active disulphides

Homeobox-containing protein 1

Intramolecular

Cysteine 278 and cysteine 304

A redox-regulated disulphide may form within Homeobox-containing protein 1 between cysteines 278 and 304.

Details

Redox score ?

70

PDB code

Structure name

structure of a novel telomere repeat binding protein bound to dna

Structure deposition date

2013-02-01

Thiol separation (Å)

4

Half-sphere exposure sum ?

61

Minimum pK_a ?

10

% buried

48

Peptide accession

Residue number A

278

Residue number B

304

Peptide name

Homeobox-containing protein 1

Ligandability

Cysteine 278 of Homeobox-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of Homeobox-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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