Repulsive guidance molecule B
Intermolecular
Cysteine 139 and cysteine 226
Cysteine 163 and cysteine 312
Cysteine 163 and cysteine 316
Intramolecular
Cysteine 82 and cysteine 121
Cysteine 54 and cysteine 99
Cysteine 181 and cysteine 316
Cysteine 59 and cysteine 91
Cysteine 59 and cysteine 99
Cysteine 54 and cysteine 59
Cysteine 91 and cysteine 99
More...Cysteine 54 and cysteine 91
Cysteine 312 and cysteine 316
4ui2 C 139 D 226
A redox-regulated disulphide may form between two units of Repulsive guidance molecule B at cysteines 139 and 226.
Details
Redox score ?
87
PDB code
4ui2
Structure name
crystal structure of the ternary rgmb-bmp2-neo1 complex
Structure deposition date
2015-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide A name
Repulsive guidance molecule B
Peptide B name
Repulsive guidance molecule B
Peptide A accession
Q6NW40
Peptide B accession
Q6NW40
Peptide A residue number
139
Peptide B residue number
226
Ligandability
Cysteine 139 of Repulsive guidance molecule B
Cysteine 226 of Repulsive guidance molecule B
7ne0 C 163 D 312
A redox-regulated disulphide may form between two units of Repulsive guidance molecule B at cysteines 163 and 312.
Details
Redox score ?
82
PDB code
7ne0
Structure name
structure of the ternary complex between netrin-1, repulsive-guidance molecule-b (rgmb) and neogenin
Structure deposition date
2021-02-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
Repulsive guidance molecule B
Peptide B name
Repulsive guidance molecule B
Peptide A accession
Q6NW40
Peptide B accession
Q6NW40
Peptide A residue number
163
Peptide B residue number
312
Ligandability
Cysteine 163 of Repulsive guidance molecule B
Cysteine 312 of Repulsive guidance molecule B
4bq6 E 163 F 316
A redox-regulated disulphide may form between two units of Repulsive guidance molecule B at cysteines 163 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
4bq6
Structure name
crystal structure of the rgmb-neo1 complex form 1
Structure deposition date
2013-05-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
Repulsive guidance molecule B
Peptide B name
Repulsive guidance molecule B
Peptide A accession
Q6NW40
Peptide B accession
Q6NW40
Peptide A residue number
163
Peptide B residue number
316
Ligandability
Cysteine 163 of Repulsive guidance molecule B
Cysteine 316 of Repulsive guidance molecule B
4ui0 C 82 C 121
A redox-regulated disulphide may form within Repulsive guidance molecule B between cysteines 82 and 121.
Details
Redox score ?
94
PDB code
4ui0
Structure name
crystal structure of the human rgmb-bmp2 complex, crystal form 2
Structure deposition date
2015-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NW40
Residue number A
82
Residue number B
121
Peptide name
Repulsive guidance molecule B
Ligandability
Cysteine 82 of Repulsive guidance molecule B
Cysteine 121 of Repulsive guidance molecule B
4ui2 C 54 C 99
A redox-regulated disulphide may form within Repulsive guidance molecule B between cysteines 54 and 99.
Details
Redox score ?
87
PDB code
4ui2
Structure name
crystal structure of the ternary rgmb-bmp2-neo1 complex
Structure deposition date
2015-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NW40
Residue number A
54
Residue number B
99
Peptide name
Repulsive guidance molecule B
Ligandability
Cysteine 54 of Repulsive guidance molecule B
Cysteine 99 of Repulsive guidance molecule B
4bq7 D 181 D 316
A redox-regulated disulphide may form within Repulsive guidance molecule B between cysteines 181 and 316.
Details
Redox score ?
84
PDB code
4bq7
Structure name
crystal structure of the rgmb-neo1 complex form 2
Structure deposition date
2013-05-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NW40
Residue number A
181
Residue number B
316
Peptide name
Repulsive guidance molecule B
Ligandability
Cysteine 181 of Repulsive guidance molecule B
Cysteine 316 of Repulsive guidance molecule B
4ui2 C 59 C 91
A redox-regulated disulphide may form within Repulsive guidance molecule B between cysteines 59 and 91.
Details
Redox score ?
83
PDB code
4ui2
Structure name
crystal structure of the ternary rgmb-bmp2-neo1 complex
Structure deposition date
2015-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NW40
Residue number A
59
Residue number B
91
Peptide name
Repulsive guidance molecule B
Ligandability
Cysteine 59 of Repulsive guidance molecule B
Cysteine 91 of Repulsive guidance molecule B
4ui2 C 59 C 99
A redox-regulated disulphide may form within Repulsive guidance molecule B between cysteines 59 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
4ui2
Structure name
crystal structure of the ternary rgmb-bmp2-neo1 complex
Structure deposition date
2015-03-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NW40
Residue number A
59
Residue number B
99
Peptide name
Repulsive guidance molecule B
Ligandability
Cysteine 59 of Repulsive guidance molecule B
Cysteine 99 of Repulsive guidance molecule B
4ui2 C 54 C 59
A redox-regulated disulphide may form within Repulsive guidance molecule B between cysteines 54 and 59. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
4ui2
Structure name
crystal structure of the ternary rgmb-bmp2-neo1 complex
Structure deposition date
2015-03-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NW40
Residue number A
54
Residue number B
59
Peptide name
Repulsive guidance molecule B
Ligandability
Cysteine 54 of Repulsive guidance molecule B
Cysteine 59 of Repulsive guidance molecule B
4ui2 C 91 C 99
A redox-regulated disulphide may form within Repulsive guidance molecule B between cysteines 91 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
4ui2
Structure name
crystal structure of the ternary rgmb-bmp2-neo1 complex
Structure deposition date
2015-03-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NW40
Residue number A
91
Residue number B
99
Peptide name
Repulsive guidance molecule B
Ligandability
Cysteine 91 of Repulsive guidance molecule B
Cysteine 99 of Repulsive guidance molecule B
4ui2 C 54 C 91
A redox-regulated disulphide may form within Repulsive guidance molecule B between cysteines 54 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4ui2
Structure name
crystal structure of the ternary rgmb-bmp2-neo1 complex
Structure deposition date
2015-03-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NW40
Residue number A
54
Residue number B
91
Peptide name
Repulsive guidance molecule B
Ligandability
Cysteine 54 of Repulsive guidance molecule B
Cysteine 91 of Repulsive guidance molecule B
4bq6 F 312 F 316
A redox-regulated disulphide may form within Repulsive guidance molecule B between cysteines 312 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4bq6
Structure name
crystal structure of the rgmb-neo1 complex form 1
Structure deposition date
2013-05-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NW40
Residue number A
312
Residue number B
316
Peptide name
Repulsive guidance molecule B
Ligandability
Cysteine 312 of Repulsive guidance molecule B
Cysteine 316 of Repulsive guidance molecule B
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