ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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LLGL scribble cell polarity complex component 2

Intramolecular
Cysteine 889 and cysteine 901
Cysteine 248 and cysteine 255
A redox-regulated disulphide may form within LLGL scribble cell polarity complex component 2 between cysteines 889 and 901. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6n8q
Structure name
crystal structure of the human cell polarity protein lethal giant larvae 2 (lgl2)
Structure deposition date
2018-11-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
91
Peptide accession
Q6P1M3
Residue number A
889
Residue number B
901
Peptide name
LLGL scribble cell polarity complex component 2

Ligandability

Cysteine 889 of LLGL scribble cell polarity complex component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 901 of LLGL scribble cell polarity complex component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within LLGL scribble cell polarity complex component 2 between cysteines 248 and 255. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6n8s
Structure name
crystal structure of the human cell polarity protein lethal giant larvae 2 (lgl2)
Structure deposition date
2018-11-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
10
% buried
77
Peptide accession
Q6P1M3
Residue number A
248
Residue number B
255
Peptide name
LLGL scribble cell polarity complex component 2

Ligandability

Cysteine 248 of LLGL scribble cell polarity complex component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of LLGL scribble cell polarity complex component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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