ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Deoxyribonuclease TATDN1

Intramolecular
Cysteine 198 and cysteine 226 L
Cysteine 253 and cysteine 261
Cysteine 76 and cysteine 81
Cysteine 81 and cysteine 123
Cysteine 76 and cysteine 123
Cysteine 113 and cysteine 168 L
Cysteine 81 and cysteine 113 L
Cysteine 76 and cysteine 113 L
A redox-regulated disulphide may form within Deoxyribonuclease TATDN1 between cysteines 198 and 226.

Details

Redox score ?
78
PDB code
2xio
Structure name
structure of putative deoxyribonuclease tatdn1 isoform a
Structure deposition date
2010-06-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6P1N9
Residue number A
198
Residue number B
226
Peptide name
Deoxyribonuclease TATDN1

Ligandability

Cysteine 198 of Deoxyribonuclease TATDN1

Cysteine 226 of Deoxyribonuclease TATDN1

A redox-regulated disulphide may form within Deoxyribonuclease TATDN1 between cysteines 253 and 261.

Details

Redox score ?
75
PDB code
2xio
Structure name
structure of putative deoxyribonuclease tatdn1 isoform a
Structure deposition date
2010-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
6
% buried
74
Peptide accession
Q6P1N9
Residue number A
253
Residue number B
261
Peptide name
Deoxyribonuclease TATDN1

Ligandability

Cysteine 253 of Deoxyribonuclease TATDN1

Cysteine 261 of Deoxyribonuclease TATDN1

A redox-regulated disulphide may form within Deoxyribonuclease TATDN1 between cysteines 76 and 81.

Details

Redox score ?
67
PDB code
2xio
Structure name
structure of putative deoxyribonuclease tatdn1 isoform a
Structure deposition date
2010-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
96
Peptide accession
Q6P1N9
Residue number A
76
Residue number B
81
Peptide name
Deoxyribonuclease TATDN1

Ligandability

Cysteine 76 of Deoxyribonuclease TATDN1

Cysteine 81 of Deoxyribonuclease TATDN1

A redox-regulated disulphide may form within Deoxyribonuclease TATDN1 between cysteines 81 and 123.

Details

Redox score ?
62
PDB code
2xio
Structure name
structure of putative deoxyribonuclease tatdn1 isoform a
Structure deposition date
2010-06-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
70
Peptide accession
Q6P1N9
Residue number A
81
Residue number B
123
Peptide name
Deoxyribonuclease TATDN1

Ligandability

Cysteine 81 of Deoxyribonuclease TATDN1

Cysteine 123 of Deoxyribonuclease TATDN1

A redox-regulated disulphide may form within Deoxyribonuclease TATDN1 between cysteines 76 and 123. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2xio
Structure name
structure of putative deoxyribonuclease tatdn1 isoform a
Structure deposition date
2010-06-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
9
% buried
66
Peptide accession
Q6P1N9
Residue number A
76
Residue number B
123
Peptide name
Deoxyribonuclease TATDN1

Ligandability

Cysteine 76 of Deoxyribonuclease TATDN1

Cysteine 123 of Deoxyribonuclease TATDN1

A redox-regulated disulphide may form within Deoxyribonuclease TATDN1 between cysteines 113 and 168. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2xio
Structure name
structure of putative deoxyribonuclease tatdn1 isoform a
Structure deposition date
2010-06-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
86
Peptide accession
Q6P1N9
Residue number A
113
Residue number B
168
Peptide name
Deoxyribonuclease TATDN1

Ligandability

Cysteine 113 of Deoxyribonuclease TATDN1

Cysteine 168 of Deoxyribonuclease TATDN1

A redox-regulated disulphide may form within Deoxyribonuclease TATDN1 between cysteines 81 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2xio
Structure name
structure of putative deoxyribonuclease tatdn1 isoform a
Structure deposition date
2010-06-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
13
% buried
100
Peptide accession
Q6P1N9
Residue number A
81
Residue number B
113
Peptide name
Deoxyribonuclease TATDN1

Ligandability

Cysteine 81 of Deoxyribonuclease TATDN1

Cysteine 113 of Deoxyribonuclease TATDN1

A redox-regulated disulphide may form within Deoxyribonuclease TATDN1 between cysteines 76 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2xio
Structure name
structure of putative deoxyribonuclease tatdn1 isoform a
Structure deposition date
2010-06-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
93
Minimum pKa ?
9
% buried
96
Peptide accession
Q6P1N9
Residue number A
76
Residue number B
113
Peptide name
Deoxyribonuclease TATDN1

Ligandability

Cysteine 76 of Deoxyribonuclease TATDN1

Cysteine 113 of Deoxyribonuclease TATDN1

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