ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Transcription initiation factor TFIID subunit 2

Intramolecular
Cysteine 729 and cysteine 732
Cysteine 728 and cysteine 729
Cysteine 945 and cysteine 986
Cysteine 728 and cysteine 732
Cysteine 70 and cysteine 192
Cysteine 192 and cysteine 200
Cysteine 699 and cysteine 701
A redox-regulated disulphide may form within Transcription initiation factor TFIID subunit 2 between cysteines 729 and 732. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
5fur
Structure name
structure of human tfiid-iia bound to core promoter dna
Structure deposition date
2016-01-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
38
Peptide accession
Q6P1X5
Residue number A
729
Residue number B
732
Peptide name
Transcription initiation factor TFIID subunit 2

Ligandability

Cysteine 729 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 732 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription initiation factor TFIID subunit 2 between cysteines 728 and 729. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6mzm
Structure name
human tfiid bound to promoter dna and tfiia
Structure deposition date
2018-11-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
18
Peptide accession
Q6P1X5
Residue number A
728
Residue number B
729
Peptide name
Transcription initiation factor TFIID subunit 2

Ligandability

Cysteine 728 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 729 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription initiation factor TFIID subunit 2 between cysteines 945 and 986. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6mzc
Structure name
human tfiid bc core
Structure deposition date
2018-11-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
40
Peptide accession
Q6P1X5
Residue number A
945
Residue number B
986
Peptide name
Transcription initiation factor TFIID subunit 2

Ligandability

Cysteine 945 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 986 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription initiation factor TFIID subunit 2 between cysteines 728 and 732. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7egd
Structure name
scp promoter-bound tfiid-tfiia in initial tbp-loading state
Structure deposition date
2021-03-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
32
Peptide accession
Q6P1X5
Residue number A
728
Residue number B
732
Peptide name
Transcription initiation factor TFIID subunit 2

Ligandability

Cysteine 728 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 732 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription initiation factor TFIID subunit 2 between cysteines 70 and 192. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7ege
Structure name
tfiid in canonical conformation
Structure deposition date
2021-03-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
Q6P1X5
Residue number A
70
Residue number B
192
Peptide name
Transcription initiation factor TFIID subunit 2

Ligandability

Cysteine 70 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription initiation factor TFIID subunit 2 between cysteines 192 and 200. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6mzm
Structure name
human tfiid bound to promoter dna and tfiia
Structure deposition date
2018-11-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
Q6P1X5
Residue number A
192
Residue number B
200
Peptide name
Transcription initiation factor TFIID subunit 2

Ligandability

Cysteine 192 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription initiation factor TFIID subunit 2 between cysteines 699 and 701. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6mzl
Structure name
human tfiid canonical state
Structure deposition date
2018-11-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
94
Peptide accession
Q6P1X5
Residue number A
699
Residue number B
701
Peptide name
Transcription initiation factor TFIID subunit 2

Ligandability

Cysteine 699 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 701 of Transcription initiation factor TFIID subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: