ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mediator of RNA polymerase II transcription subunit 27

Intramolecular
Cysteine 281 and cysteine 284
Cysteine 281 and cysteine 309
Cysteine 284 and cysteine 309
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 27 between cysteines 281 and 284.

Details

Redox score ?
84
PDB code
7nvr
Structure name
human mediator with rna polymerase ii pre-initiation complex
Structure deposition date
2021-03-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
7
% buried
23
Peptide accession
Q6P2C8
Residue number A
281
Residue number B
284
Peptide name
Mediator of RNA polymerase II transcription subunit 27

Ligandability

Cysteine 281 of Mediator of RNA polymerase II transcription subunit 27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Mediator of RNA polymerase II transcription subunit 27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 27 between cysteines 281 and 309.

Details

Redox score ?
81
PDB code
7nvr
Structure name
human mediator with rna polymerase ii pre-initiation complex
Structure deposition date
2021-03-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
26
Peptide accession
Q6P2C8
Residue number A
281
Residue number B
309
Peptide name
Mediator of RNA polymerase II transcription subunit 27

Ligandability

Cysteine 281 of Mediator of RNA polymerase II transcription subunit 27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Mediator of RNA polymerase II transcription subunit 27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 27 between cysteines 284 and 309.

Details

Redox score ?
73
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
52
Peptide accession
Q6P2C8
Residue number A
284
Residue number B
309
Peptide name
Mediator of RNA polymerase II transcription subunit 27

Ligandability

Cysteine 284 of Mediator of RNA polymerase II transcription subunit 27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Mediator of RNA polymerase II transcription subunit 27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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