a tool for identifying drug-targetable redox-active disulphides

DnaJ homolog subfamily C member 24

Intramolecular

Cysteine 115 and cysteine 136

Cysteine 115 and cysteine 117

Cysteine 136 and cysteine 139

Cysteine 117 and cysteine 136

Cysteine 117 and cysteine 139

Cysteine 115 and cysteine 139

Cysteine 83 and cysteine 117

A redox-regulated disulphide may form within DnaJ homolog subfamily C member 24 between cysteines 115 and 136.

Details

Redox score ?

87

PDB code

Structure name

solution structure of human j-protein co-chaperone, dph4

Structure deposition date

2010-11-23

Thiol separation (Å)

4

Half-sphere exposure sum ?

50

Minimum pK_a ?

8

% buried

2

Peptide accession

Residue number A

115

Residue number B

136

Peptide name

DnaJ homolog subfamily C member 24

Ligandability

Cysteine 115 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DnaJ homolog subfamily C member 24 between cysteines 115 and 117.

Details

Redox score ?

86

PDB code

Structure name

solution structure of human j-protein co-chaperone, dph4

Structure deposition date

2010-11-23

Thiol separation (Å)

4

Half-sphere exposure sum ?

36

Minimum pK_a ?

8

% buried

1

Peptide accession

Residue number A

115

Residue number B

117

Peptide name

DnaJ homolog subfamily C member 24

Ligandability

Cysteine 115 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DnaJ homolog subfamily C member 24 between cysteines 136 and 139.

Details

Redox score ?

85

PDB code

Structure name

solution structure of human j-protein co-chaperone, dph4

Structure deposition date

2010-11-23

Thiol separation (Å)

4

Half-sphere exposure sum ?

42

Minimum pK_a ?

8

% buried

0

Peptide accession

Residue number A

136

Residue number B

139

Peptide name

DnaJ homolog subfamily C member 24

Ligandability

Cysteine 136 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DnaJ homolog subfamily C member 24 between cysteines 117 and 136.

Details

Redox score ?

85

PDB code

Structure name

solution structure of human j-protein co-chaperone, dph4

Structure deposition date

2010-11-23

Thiol separation (Å)

4

Half-sphere exposure sum ?

38

Minimum pK_a ?

8

% buried

0

Peptide accession

Residue number A

117

Residue number B

136

Peptide name

DnaJ homolog subfamily C member 24

Ligandability

Cysteine 117 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DnaJ homolog subfamily C member 24 between cysteines 117 and 139.

Details

Redox score ?

85

PDB code

Structure name

solution structure of human j-protein co-chaperone, dph4

Structure deposition date

2010-11-23

Thiol separation (Å)

4

Half-sphere exposure sum ?

28

Minimum pK_a ?

8

% buried

0

Peptide accession

Residue number A

117

Residue number B

139

Peptide name

DnaJ homolog subfamily C member 24

Ligandability

Cysteine 117 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DnaJ homolog subfamily C member 24 between cysteines 115 and 139.

Details

Redox score ?

83

PDB code

Structure name

solution structure of human j-protein co-chaperone, dph4

Structure deposition date

2010-11-23

Thiol separation (Å)

4

Half-sphere exposure sum ?

40

Minimum pK_a ?

9

% buried

1

Peptide accession

Residue number A

115

Residue number B

139

Peptide name

DnaJ homolog subfamily C member 24

Ligandability

Cysteine 115 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DnaJ homolog subfamily C member 24 between cysteines 83 and 117. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

52

PDB code

Structure name

solution structure of human j-protein co-chaperone, dph4

Structure deposition date

2010-11-23

Thiol separation (Å)

9

Half-sphere exposure sum ?

29

Minimum pK_a ?

8

% buried

0

Peptide accession

Residue number A

83

Residue number B

117

Peptide name

DnaJ homolog subfamily C member 24

Ligandability

Cysteine 83 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of DnaJ homolog subfamily C member 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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