ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Phospholipase B-like 1

Intramolecular
Cysteine 467 and cysteine 472
Cysteine 471 and cysteine 486
Cysteine 472 and cysteine 486
Cysteine 471 and cysteine 472
Cysteine 467 and cysteine 486
Cysteine 467 and cysteine 471
A redox-regulated disulphide may form within Phospholipase B-like 1 between cysteines 467 and 472.

Details

Redox score ?
79
PDB code
4bwc
Structure name
x-ray structure of a phospholiapse b like protein 1 from bovine kidneys
Structure deposition date
2013-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9GL30
Residue number A
467
Residue number B
472
Peptide name
Phospholipase B-like 1

Ligandability

Cysteine 467 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phospholipase B-like 1 between cysteines 471 and 486.

Details

Redox score ?
78
PDB code
4bwc
Structure name
x-ray structure of a phospholiapse b like protein 1 from bovine kidneys
Structure deposition date
2013-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9GL30
Residue number A
471
Residue number B
486
Peptide name
Phospholipase B-like 1

Ligandability

Cysteine 471 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 486 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phospholipase B-like 1 between cysteines 472 and 486. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4bwc
Structure name
x-ray structure of a phospholiapse b like protein 1 from bovine kidneys
Structure deposition date
2013-07-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9GL30
Residue number A
472
Residue number B
486
Peptide name
Phospholipase B-like 1

Ligandability

Cysteine 472 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 486 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phospholipase B-like 1 between cysteines 471 and 472. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4bwc
Structure name
x-ray structure of a phospholiapse b like protein 1 from bovine kidneys
Structure deposition date
2013-07-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9GL30
Residue number A
471
Residue number B
472
Peptide name
Phospholipase B-like 1

Ligandability

Cysteine 471 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phospholipase B-like 1 between cysteines 467 and 486. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4bwc
Structure name
x-ray structure of a phospholiapse b like protein 1 from bovine kidneys
Structure deposition date
2013-07-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9GL30
Residue number A
467
Residue number B
486
Peptide name
Phospholipase B-like 1

Ligandability

Cysteine 467 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 486 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phospholipase B-like 1 between cysteines 467 and 471. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4bwc
Structure name
x-ray structure of a phospholiapse b like protein 1 from bovine kidneys
Structure deposition date
2013-07-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9GL30
Residue number A
467
Residue number B
471
Peptide name
Phospholipase B-like 1

Ligandability

Cysteine 467 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 471 of Phospholipase B-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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