ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TRA@ protein

Intramolecular
Cysteine 27 and cysteine 93
Cysteine 142 and cysteine 192
A redox-regulated disulphide may form within TRA@ protein between cysteines 27 and 93 (22 and 90 respectively in this structure).

Details

Redox score ?
81
PDB code
2nw2
Structure name
crystal structure of els4 tcr at 1
Structure deposition date
2006-11-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6P4G7
Residue number A
27
Residue number B
93
Peptide name
TRA@ protein

Ligandability

Cysteine 27 of TRA@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of TRA@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TRA@ protein between cysteines 142 and 192 (133 and 183 respectively in this structure).

Details

Redox score ?
75
PDB code
5wki
Structure name
crystal structure of pg90 tcr-cd1b-pg complex
Structure deposition date
2017-07-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
7
% buried
74
Peptide accession
Q6P4G7
Residue number A
142
Residue number B
192
Peptide name
TRA@ protein

Ligandability

Cysteine 142 of TRA@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of TRA@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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