ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Acylpyruvase FAHD1, mitochondrial

Intramolecular
Cysteine 100 and cysteine 129
Cysteine 22 and cysteine 129
Cysteine 22 and cysteine 100
A redox-regulated disulphide may form within Acylpyruvase FAHD1, mitochondrial between cysteines 100 and 129.

Details

Redox score ?
64
PDB code
1saw
Structure name
x-ray structure of homo sapiens protein flj36880
Structure deposition date
2004-02-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
100
Minimum pKa ?
8
% buried
100
Peptide accession
Q6P587
Residue number A
100
Residue number B
129
Peptide name
Acylpyruvase FAHD1, mitochondrial

Ligandability

Cysteine 100 of Acylpyruvase FAHD1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Acylpyruvase FAHD1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Acylpyruvase FAHD1, mitochondrial between cysteines 22 and 129. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6fog
Structure name
x-ray structure of homo sapiens fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate at 1
Structure deposition date
2018-02-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
91
Minimum pKa ?
8
% buried
100
Peptide accession
Q6P587
Residue number A
22
Residue number B
129
Peptide name
Acylpyruvase FAHD1, mitochondrial

Ligandability

Cysteine 22 of Acylpyruvase FAHD1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Acylpyruvase FAHD1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Acylpyruvase FAHD1, mitochondrial between cysteines 22 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6fog
Structure name
x-ray structure of homo sapiens fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate at 1
Structure deposition date
2018-02-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
95
Minimum pKa ?
13
% buried
100
Peptide accession
Q6P587
Residue number A
22
Residue number B
100
Peptide name
Acylpyruvase FAHD1, mitochondrial

Ligandability

Cysteine 22 of Acylpyruvase FAHD1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Acylpyruvase FAHD1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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