ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Ribonuclease kappa

Intramolecular
Cysteine 45 and cysteine 46
Cysteine 46 and cysteine 53
Cysteine 45 and cysteine 124
A redox-regulated disulphide may form within Ribonuclease kappa between cysteines 45 and 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6wm3
Structure name
human v-atpase in state 2 with sidk and adp
Structure deposition date
2020-04-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide accession
Q6P5S7
Residue number A
45
Residue number B
46
Peptide name
Ribonuclease kappa

Ligandability

Cysteine 45 of Ribonuclease kappa

Cysteine 46 of Ribonuclease kappa

A redox-regulated disulphide may form within Ribonuclease kappa between cysteines 46 and 53. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6wm2
Structure name
human v-atpase in state 1 with sidk and adp
Structure deposition date
2020-04-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
6
Peptide accession
Q6P5S7
Residue number A
46
Residue number B
53
Peptide name
Ribonuclease kappa

Ligandability

Cysteine 46 of Ribonuclease kappa

Cysteine 53 of Ribonuclease kappa

A redox-regulated disulphide may form within Ribonuclease kappa between cysteines 45 and 124. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6wm4
Structure name
human v-atpase in state 3 with sidk and adp
Structure deposition date
2020-04-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide accession
Q6P5S7
Residue number A
45
Residue number B
124
Peptide name
Ribonuclease kappa

Ligandability

Cysteine 45 of Ribonuclease kappa

Cysteine 124 of Ribonuclease kappa

If this tool was useful for finding a disulphide, please cite: