ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

IGK@ protein

Intramolecular
Cysteine 43 and cysteine 109
Cysteine 156 and cysteine 216
A redox-regulated disulphide may form within IGK@ protein between cysteines 43 and 109 (23 and 88 respectively in this structure).

Details

Redox score ?
79
PDB code
5wko
Structure name
crystal structure of antibody 27f3 recognizing the ha from a/california/04/2009 (h1n1) influenza virus
Structure deposition date
2017-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6P5S8
Residue number A
43
Residue number B
109
Peptide name
IGK@ protein

Ligandability

Cysteine 43 of IGK@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of IGK@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGK@ protein between cysteines 156 and 216 (138 and 198 respectively in this structure).

Details

Redox score ?
77
PDB code
6al5
Structure name
complex between cd19 (n138q mutant) and b43 fab
Structure deposition date
2017-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6P5S8
Residue number A
156
Residue number B
216
Peptide name
IGK@ protein

Ligandability

Cysteine 156 of IGK@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of IGK@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: