ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RNA demethylase ALKBH5

Intermolecular
Cysteine 200 and cysteine 200
Intramolecular
Cysteine 230 and cysteine 267
Cysteine 227 and cysteine 267
Cysteine 227 and cysteine 230
Cysteine 200 and cysteine 267
Cysteine 200 and cysteine 227
Cysteine 200 and cysteine 230
A redox-regulated disulphide may form between two units of RNA demethylase ALKBH5 at cysteines 200 and 200. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4nj4
Structure name
crystal structure of human alkbh5
Structure deposition date
2013-11-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
15
% buried
100
Peptide A name
RNA demethylase ALKBH5
Peptide B name
RNA demethylase ALKBH5
Peptide A accession
Q6P6C2
Peptide B accession
Q6P6C2
Peptide A residue number
200
Peptide B residue number
200

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA demethylase ALKBH5 between cysteines 230 and 267.

Details

Redox score ?
71
PDB code
7wkv
Structure name
crystal structure of human alkbh5 in complex with 2-oxoglutarate (2og) and m6a-containing ssrna
Structure deposition date
2022-01-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
60
Peptide accession
Q6P6C2
Residue number A
230
Residue number B
267
Peptide name
RNA demethylase ALKBH5

Ligandability

Cysteine 230 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 267 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA demethylase ALKBH5 between cysteines 227 and 267.

Details

Redox score ?
64
PDB code
4oct
Structure name
crystal structure of human alkbh5 crystallized in the presence of mn^{2+} and 2-oxoglutarate
Structure deposition date
2014-01-09
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6P6C2
Residue number A
227
Residue number B
267
Peptide name
RNA demethylase ALKBH5

Ligandability

Cysteine 227 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 267 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA demethylase ALKBH5 between cysteines 227 and 230.

Details

Redox score ?
63
PDB code
7v4g
Structure name
crystal structure of human alkbh5 in complex with m6a-containing ssrna
Structure deposition date
2021-08-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
12
% buried
54
Peptide accession
Q6P6C2
Residue number A
227
Residue number B
230
Peptide name
RNA demethylase ALKBH5

Ligandability

Cysteine 227 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA demethylase ALKBH5 between cysteines 200 and 267. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4nrp
Structure name
crystal structure of human alkbh5 in complex with n-oxalylglycine
Structure deposition date
2013-11-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
nan
Peptide accession
Q6P6C2
Residue number A
200
Residue number B
267
Peptide name
RNA demethylase ALKBH5

Ligandability

Cysteine 200 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 267 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA demethylase ALKBH5 between cysteines 200 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
4nj4
Structure name
crystal structure of human alkbh5
Structure deposition date
2013-11-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
90
Peptide accession
Q6P6C2
Residue number A
200
Residue number B
227
Peptide name
RNA demethylase ALKBH5

Ligandability

Cysteine 200 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 227 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA demethylase ALKBH5 between cysteines 200 and 230. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
4nj4
Structure name
crystal structure of human alkbh5
Structure deposition date
2013-11-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
16
% buried
nan
Peptide accession
Q6P6C2
Residue number A
200
Residue number B
230
Peptide name
RNA demethylase ALKBH5

Ligandability

Cysteine 200 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of RNA demethylase ALKBH5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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