ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Proteasome (Prosome, macropain) 26S subunit, ATPase 3

Intermolecular
Cysteine 156 of Proteasome subunit alpha type-1 and cysteine 390
Cysteine 148 of Proteasome subunit alpha type-1 and cysteine 390
Intramolecular
Cysteine 399 and cysteine 403
A redox-regulated disulphide may form between cysteine 156 of Proteasome subunit alpha type-1 and cysteine 390 of Proteasome (Prosome, macropain) 26S subunit, ATPase 3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6epc
Structure name
ground state 26s proteasome (gs2)
Structure deposition date
2017-10-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
100
Peptide A name
Proteasome subunit alpha type-1
Peptide B name
Proteasome (Prosome, macropain) 26S subunit, ATPase 3
Peptide A accession
P18420
Peptide B accession
Q6P6U2
Peptide A residue number
156
Peptide B residue number
390

Ligandability

Cysteine 156 of Proteasome subunit alpha type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 390 of Proteasome (Prosome, macropain) 26S subunit, ATPase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 148 of Proteasome subunit alpha type-1 and cysteine 390 of Proteasome (Prosome, macropain) 26S subunit, ATPase 3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6epc
Structure name
ground state 26s proteasome (gs2)
Structure deposition date
2017-10-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
9
% buried
100
Peptide A name
Proteasome subunit alpha type-1
Peptide B name
Proteasome (Prosome, macropain) 26S subunit, ATPase 3
Peptide A accession
P18420
Peptide B accession
Q6P6U2
Peptide A residue number
148
Peptide B residue number
390

Ligandability

Cysteine 148 of Proteasome subunit alpha type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 390 of Proteasome (Prosome, macropain) 26S subunit, ATPase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proteasome (Prosome, macropain) 26S subunit, ATPase 3 between cysteines 399 and 403. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6epd
Structure name
substrate processing state 26s proteasome (sps1)
Structure deposition date
2017-10-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
100
Minimum pKa ?
11
% buried
100
Peptide accession
Q6P6U2
Residue number A
399
Residue number B
403
Peptide name
Proteasome (Prosome, macropain) 26S subunit, ATPase 3

Ligandability

Cysteine 399 of Proteasome (Prosome, macropain) 26S subunit, ATPase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 403 of Proteasome (Prosome, macropain) 26S subunit, ATPase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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