ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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E3 ubiquitin-protein ligase RFWD3

Intramolecular
Cysteine 638 and cysteine 696
Cysteine 456 and cysteine 461
Cysteine 650 and cysteine 684
Cysteine 546 and cysteine 548
Cysteine 545 and cysteine 546
Cysteine 682 and cysteine 684
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RFWD3 between cysteines 638 and 696.

Details

Redox score ?
82
PDB code
6cvz
Structure name
crystal structure of the wd40-repeat of rfwd3
Structure deposition date
2018-03-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PCD5
Residue number A
638
Residue number B
696
Peptide name
E3 ubiquitin-protein ligase RFWD3

Ligandability

Cysteine 638 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 696 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RFWD3 between cysteines 456 and 461. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6cvz
Structure name
crystal structure of the wd40-repeat of rfwd3
Structure deposition date
2018-03-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
46
Peptide accession
Q6PCD5
Residue number A
456
Residue number B
461
Peptide name
E3 ubiquitin-protein ligase RFWD3

Ligandability

Cysteine 456 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 461 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RFWD3 between cysteines 650 and 684. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6cvz
Structure name
crystal structure of the wd40-repeat of rfwd3
Structure deposition date
2018-03-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
89
Peptide accession
Q6PCD5
Residue number A
650
Residue number B
684
Peptide name
E3 ubiquitin-protein ligase RFWD3

Ligandability

Cysteine 650 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 684 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RFWD3 between cysteines 546 and 548. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6cvz
Structure name
crystal structure of the wd40-repeat of rfwd3
Structure deposition date
2018-03-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
10
% buried
86
Peptide accession
Q6PCD5
Residue number A
546
Residue number B
548
Peptide name
E3 ubiquitin-protein ligase RFWD3

Ligandability

Cysteine 546 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 548 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RFWD3 between cysteines 545 and 546. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6cvz
Structure name
crystal structure of the wd40-repeat of rfwd3
Structure deposition date
2018-03-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
Q6PCD5
Residue number A
545
Residue number B
546
Peptide name
E3 ubiquitin-protein ligase RFWD3

Ligandability

Cysteine 545 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 546 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RFWD3 between cysteines 682 and 684. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6cvz
Structure name
crystal structure of the wd40-repeat of rfwd3
Structure deposition date
2018-03-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
12
% buried
71
Peptide accession
Q6PCD5
Residue number A
682
Residue number B
684
Peptide name
E3 ubiquitin-protein ligase RFWD3

Ligandability

Cysteine 682 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 684 of E3 ubiquitin-protein ligase RFWD3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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