ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RNA polymerase-associated protein CTR9 homolog

Intermolecular
Cysteine 511 and cysteine 266 of SKI8 subunit of superkiller complex protein
Intramolecular
Cysteine 136 and cysteine 138 L
Cysteine 136 and cysteine 171 L
A redox-regulated disulphide may form between cysteine 511 of RNA polymerase-associated protein CTR9 homolog and cysteine 266 of SKI8 subunit of superkiller complex protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6ted
Structure name
structure of complete, activated transcription complex pol ii-dsif- paf-spt6 uncovers allosteric elongation activation by rtf1
Structure deposition date
2019-11-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
60
Peptide A name
RNA polymerase-associated protein CTR9 homolog
Peptide B name
SKI8 subunit of superkiller complex protein
Peptide A accession
Q6PD62
Peptide B accession
Q9GZS3
Peptide A residue number
511
Peptide B residue number
266

Ligandability

Cysteine 511 of RNA polymerase-associated protein CTR9 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 266 of SKI8 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA polymerase-associated protein CTR9 homolog between cysteines 136 and 138. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6ted
Structure name
structure of complete, activated transcription complex pol ii-dsif- paf-spt6 uncovers allosteric elongation activation by rtf1
Structure deposition date
2019-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
58
Peptide accession
Q6PD62
Residue number A
136
Residue number B
138
Peptide name
RNA polymerase-associated protein CTR9 homolog

Ligandability

Cysteine 136 of RNA polymerase-associated protein CTR9 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 138 of RNA polymerase-associated protein CTR9 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA polymerase-associated protein CTR9 homolog between cysteines 136 and 171. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6ted
Structure name
structure of complete, activated transcription complex pol ii-dsif- paf-spt6 uncovers allosteric elongation activation by rtf1
Structure deposition date
2019-11-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q6PD62
Residue number A
136
Residue number B
171
Peptide name
RNA polymerase-associated protein CTR9 homolog

Ligandability

Cysteine 136 of RNA polymerase-associated protein CTR9 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 171 of RNA polymerase-associated protein CTR9 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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