ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Igh protein

Intramolecular
Cysteine 41 and cysteine 115
Cysteine 161 and cysteine 216
A redox-regulated disulphide may form within Igh protein between cysteines 41 and 115 (22 and 92 respectively in this structure).

Details

Redox score ?
80
PDB code
2gsi
Structure name
crystal structure of a murine fab in complex with an 11 residue peptide derived from staphylococcal nuclease
Structure deposition date
2006-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PF95
Residue number A
41
Residue number B
115
Peptide name
Igh protein

Ligandability

Cysteine 41 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Igh protein between cysteines 161 and 216 (140 and 195 respectively in this structure).

Details

Redox score ?
77
PDB code
1xgy
Structure name
crystal structure of anti-meta i rhodopsin fab fragment k42- 41l
Structure deposition date
2004-09-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PF95
Residue number A
161
Residue number B
216
Peptide name
Igh protein

Ligandability

Cysteine 161 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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