ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

SKI3 subunit of superkiller complex protein

Intramolecular
Cysteine 1478 and cysteine 1480
Cysteine 724 and cysteine 765
Cysteine 724 and cysteine 726
Cysteine 780 and cysteine 813
Cysteine 836 and cysteine 849
A redox-regulated disulphide may form within SKI3 subunit of superkiller complex protein between cysteines 1478 and 1480.

Details

Redox score ?
65
PDB code
7qdr
Structure name
apo human ski complex in the closed state
Structure deposition date
2021-11-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
44
Peptide accession
Q6PGP7
Residue number A
1478
Residue number B
1480
Peptide name
SKI3 subunit of superkiller complex protein

Ligandability

Cysteine 1478 of SKI3 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1480 of SKI3 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SKI3 subunit of superkiller complex protein between cysteines 724 and 765. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7qdr
Structure name
apo human ski complex in the closed state
Structure deposition date
2021-11-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
11
% buried
92
Peptide accession
Q6PGP7
Residue number A
724
Residue number B
765
Peptide name
SKI3 subunit of superkiller complex protein

Ligandability

Cysteine 724 of SKI3 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 765 of SKI3 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SKI3 subunit of superkiller complex protein between cysteines 724 and 726. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7qdz
Structure name
80s-bound human ski complex in the closed state
Structure deposition date
2021-12-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
Q6PGP7
Residue number A
724
Residue number B
726
Peptide name
SKI3 subunit of superkiller complex protein

Ligandability

Cysteine 724 of SKI3 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 726 of SKI3 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SKI3 subunit of superkiller complex protein between cysteines 780 and 813. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
7qds
Structure name
apo human ski complex in the open state
Structure deposition date
2021-11-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
82
Peptide accession
Q6PGP7
Residue number A
780
Residue number B
813
Peptide name
SKI3 subunit of superkiller complex protein

Ligandability

Cysteine 780 of SKI3 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 813 of SKI3 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SKI3 subunit of superkiller complex protein between cysteines 836 and 849. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7qdr
Structure name
apo human ski complex in the closed state
Structure deposition date
2021-11-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
93
Peptide accession
Q6PGP7
Residue number A
836
Residue number B
849
Peptide name
SKI3 subunit of superkiller complex protein

Ligandability

Cysteine 836 of SKI3 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 849 of SKI3 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: