Protein cornichon homolog 2
Intermolecular
Cysteine 549 of Glutamate receptor and cysteine 9
Cysteine 549 of Glutamate receptor and cysteine 9
Cysteine 549 of Glutamate receptor 2 and cysteine 9
Cysteine 549 of Glutamate receptor and cysteine 84
Intramolecular
Cysteine 61 and cysteine 62
Cysteine 9 and cysteine 84
Cysteine 61 and cysteine 131
7lde B 528 F 9
A redox-regulated disulphide may form between cysteine 549 of Glutamate receptor and cysteine 9 of Protein cornichon homolog 2 (528 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7lde
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
78
Peptide A name
Glutamate receptor
Peptide B name
Protein cornichon homolog 2
Peptide A accession
G5E8H1
Peptide B accession
O35089
Peptide A residue number
549
Peptide B residue number
9
Ligandability
Cysteine 549 of Glutamate receptor
Cysteine 9 of Protein cornichon homolog 2
7lep D 528 E 9
A redox-regulated disulphide may form between cysteine 549 of Glutamate receptor and cysteine 9 of Protein cornichon homolog 2 (528 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7lep
Structure name
the composite lbd-tmd structure combined from all hippocampal ampar subtypes at 3
Structure deposition date
2021-01-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
86
Peptide A name
Glutamate receptor
Peptide B name
Protein cornichon homolog 2
Peptide A accession
C9K0Z0
Peptide B accession
O35089
Peptide A residue number
549
Peptide B residue number
9
Ligandability
Cysteine 549 of Glutamate receptor
Cysteine 9 of Protein cornichon homolog 2
7oca B 528 G 9
A redox-regulated disulphide may form between cysteine 549 of Glutamate receptor 2 and cysteine 9 of Protein cornichon homolog 2 (528 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7oca
Structure name
resting state full-length glua1/a2 heterotertramer in complex with tarp gamma 8 and cnih2
Structure deposition date
2021-04-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
100
Peptide A name
Glutamate receptor 2
Peptide B name
Protein cornichon homolog 2
Peptide A accession
P19491
Peptide B accession
Q5BJU5
Peptide A residue number
549
Peptide B residue number
9
Ligandability
Cysteine 549 of Glutamate receptor 2
Cysteine 9 of Protein cornichon homolog 2
7lep D 528 E 84
A redox-regulated disulphide may form between cysteine 549 of Glutamate receptor and cysteine 84 of Protein cornichon homolog 2 (528 and 84 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7lep
Structure name
the composite lbd-tmd structure combined from all hippocampal ampar subtypes at 3
Structure deposition date
2021-01-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
51
Peptide A name
Glutamate receptor
Peptide B name
Protein cornichon homolog 2
Peptide A accession
C9K0Z0
Peptide B accession
O35089
Peptide A residue number
549
Peptide B residue number
84
Ligandability
Cysteine 549 of Glutamate receptor
Cysteine 84 of Protein cornichon homolog 2
7lep F 61 F 62
A redox-regulated disulphide may form within Protein cornichon homolog 2 between cysteines 61 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7lep
Structure name
the composite lbd-tmd structure combined from all hippocampal ampar subtypes at 3
Structure deposition date
2021-01-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
0
Peptide accession
O35089
Residue number A
61
Residue number B
62
Peptide name
Protein cornichon homolog 2
Ligandability
Cysteine 61 of Protein cornichon homolog 2
Cysteine 62 of Protein cornichon homolog 2
7lde E 9 E 84
A redox-regulated disulphide may form within Protein cornichon homolog 2 between cysteines 9 and 84. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7lde
Structure name
native ampa receptor
Structure deposition date
2021-01-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
50
Peptide accession
O35089
Residue number A
9
Residue number B
84
Peptide name
Protein cornichon homolog 2
Ligandability
Cysteine 9 of Protein cornichon homolog 2
Cysteine 84 of Protein cornichon homolog 2
7oca E 61 E 131
A redox-regulated disulphide may form within Protein cornichon homolog 2 between cysteines 61 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7oca
Structure name
resting state full-length glua1/a2 heterotertramer in complex with tarp gamma 8 and cnih2
Structure deposition date
2021-04-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
11
% buried
68
Peptide accession
Q5BJU5
Residue number A
61
Residue number B
131
Peptide name
Protein cornichon homolog 2
Ligandability
Cysteine 61 of Protein cornichon homolog 2
Cysteine 131 of Protein cornichon homolog 2
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