ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Aspartate--tRNA ligase, mitochondrial

Intramolecular
Cysteine 54 and cysteine 69
Cysteine 371 and cysteine 459
A redox-regulated disulphide may form within Aspartate--tRNA ligase, mitochondrial between cysteines 54 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4ah6
Structure name
human mitochondrial aspartyl-trna synthetase
Structure deposition date
2012-02-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
99
Peptide accession
Q6PI48
Residue number A
54
Residue number B
69
Peptide name
Aspartate--tRNA ligase, mitochondrial

Ligandability

Cysteine 54 of Aspartate--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 69 of Aspartate--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Aspartate--tRNA ligase, mitochondrial between cysteines 371 and 459. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
4ah6
Structure name
human mitochondrial aspartyl-trna synthetase
Structure deposition date
2012-02-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
88
Peptide accession
Q6PI48
Residue number A
371
Residue number B
459
Peptide name
Aspartate--tRNA ligase, mitochondrial

Ligandability

Cysteine 371 of Aspartate--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 459 of Aspartate--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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