ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Unconventional myosin-VIIb

Intramolecular
Cysteine 1332 and cysteine 1352
Cysteine 1109 and cysteine 1112
Cysteine 1825 and cysteine 1840
Cysteine 1134 and cysteine 1137
Cysteine 1737 and cysteine 1767
A redox-regulated disulphide may form within Unconventional myosin-VIIb between cysteines 1332 and 1352 (1314 and 1334 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5f3y
Structure name
crystal structure of myo7b n-myth4-ferm-sh3 in complex with anks4b cen
Structure deposition date
2015-12-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
61
Peptide accession
Q99MZ6
Residue number A
1332
Residue number B
1352
Peptide name
Unconventional myosin-VIIb

Ligandability

Cysteine 1332 of Unconventional myosin-VIIb

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1352 of Unconventional myosin-VIIb

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Unconventional myosin-VIIb between cysteines 1109 and 1112 (1091 and 1094 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
5f3y
Structure name
crystal structure of myo7b n-myth4-ferm-sh3 in complex with anks4b cen
Structure deposition date
2015-12-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
98
Peptide accession
Q99MZ6
Residue number A
1109
Residue number B
1112
Peptide name
Unconventional myosin-VIIb

Ligandability

Cysteine 1109 of Unconventional myosin-VIIb

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1112 of Unconventional myosin-VIIb

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Unconventional myosin-VIIb between cysteines 1825 and 1840. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5mv7
Structure name
structure of human myosin 7b c-terminal myth4-ferm mf2 domain
Structure deposition date
2017-01-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
86
Peptide accession
Q6PIF6
Residue number A
1825
Residue number B
1840
Peptide name
Unconventional myosin-VIIb

Ligandability

Cysteine 1825 of Unconventional myosin-VIIb

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1840 of Unconventional myosin-VIIb

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Unconventional myosin-VIIb between cysteines 1134 and 1137 (1116 and 1119 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5f3y
Structure name
crystal structure of myo7b n-myth4-ferm-sh3 in complex with anks4b cen
Structure deposition date
2015-12-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
Q99MZ6
Residue number A
1134
Residue number B
1137
Peptide name
Unconventional myosin-VIIb

Ligandability

Cysteine 1134 of Unconventional myosin-VIIb

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1137 of Unconventional myosin-VIIb

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Unconventional myosin-VIIb between cysteines 1737 and 1767. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
5xbf
Structure name
crystal structure of myo7b c-terminal myth4-ferm in complex with ush1c pdz3
Structure deposition date
2017-03-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
Q6PIF6
Residue number A
1737
Residue number B
1767
Peptide name
Unconventional myosin-VIIb

Ligandability

Cysteine 1737 of Unconventional myosin-VIIb

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1767 of Unconventional myosin-VIIb

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: