ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Igh protein

Intermolecular
Cysteine 219 of If kappa light chain and cysteine 149
Intramolecular
Cysteine 41 and cysteine 117
Cysteine 41 and cysteine 384
Cysteine 161 and cysteine 216
A redox-regulated disulphide may form between cysteine 219 of If kappa light chain and cysteine 149 of Igh protein (213 and 128 respectively in this structure).

Details

Redox score ?
70
PDB code
2ipt
Structure name
pfa1 fab fragment
Structure deposition date
2006-10-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
24
Peptide A name
If kappa light chain
Peptide B name
Igh protein
Peptide A accession
A2NHM3
Peptide B accession
Q6PIP8
Peptide A residue number
219
Peptide B residue number
149

Ligandability

Cysteine 219 of If kappa light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Igh protein between cysteines 41 and 117 (22 and 96 respectively in this structure).

Details

Redox score ?
80
PDB code
4kvc
Structure name
2h2 fab fragment of immature dengue virus
Structure deposition date
2013-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PIP8
Residue number A
41
Residue number B
117
Peptide name
Igh protein

Ligandability

Cysteine 41 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Igh protein between cysteines 41 and 384 (22 and 96 respectively in this structure).

Details

Redox score ?
80
PDB code
2ai0
Structure name
anti-cocaine antibody 7
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PIP8
Residue number A
41
Residue number B
384
Peptide name
Igh protein

Ligandability

Cysteine 41 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 384 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Igh protein between cysteines 161 and 216 (140 and 195 respectively in this structure).

Details

Redox score ?
77
PDB code
2ipt
Structure name
pfa1 fab fragment
Structure deposition date
2006-10-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PIP8
Residue number A
161
Residue number B
216
Peptide name
Igh protein

Ligandability

Cysteine 161 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Igh protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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