ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fidgetin-like protein 1

Intramolecular
Cysteine 586 and cysteine 587
Cysteine 586 and cysteine 612
A redox-regulated disulphide may form within Fidgetin-like protein 1 between cysteines 586 and 587.

Details

Redox score ?
63
PDB code
3d8b
Structure name
crystal structure of human fidgetin-like protein 1 in complex with adp
Structure deposition date
2008-05-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
22
Peptide accession
Q6PIW4
Residue number A
586
Residue number B
587
Peptide name
Fidgetin-like protein 1

Ligandability

Cysteine 586 of Fidgetin-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 587 of Fidgetin-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fidgetin-like protein 1 between cysteines 586 and 612. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3d8b
Structure name
crystal structure of human fidgetin-like protein 1 in complex with adp
Structure deposition date
2008-05-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
71
Peptide accession
Q6PIW4
Residue number A
586
Residue number B
612
Peptide name
Fidgetin-like protein 1

Ligandability

Cysteine 586 of Fidgetin-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 612 of Fidgetin-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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