ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IGK@ protein

Intermolecular
Cysteine 235 and cysteine 14 of Immunoglobulin heavy constant mu
Intramolecular
Cysteine 155 and cysteine 215
Cysteine 43 and cysteine 109
A redox-regulated disulphide may form between cysteine 235 of IGK@ protein and cysteine 14 of Immunoglobulin heavy constant mu (215 and 134 respectively in this structure).

Details

Redox score ?
85
PDB code
2agj
Structure name
crystal structure of a glycosylated fab from an igm cryoglobulin with properties of a natural proteolytic antibody
Structure deposition date
2005-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
IGK@ protein
Peptide B name
Immunoglobulin heavy constant mu
Peptide A accession
Q6PJF2
Peptide B accession
P01871
Peptide A residue number
235
Peptide B residue number
14

Ligandability

Cysteine 235 of IGK@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 14 of Immunoglobulin heavy constant mu

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGK@ protein between cysteines 155 and 215 (135 and 195 respectively in this structure).

Details

Redox score ?
78
PDB code
2agj
Structure name
crystal structure of a glycosylated fab from an igm cryoglobulin with properties of a natural proteolytic antibody
Structure deposition date
2005-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PJF2
Residue number A
155
Residue number B
215
Peptide name
IGK@ protein

Ligandability

Cysteine 155 of IGK@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 215 of IGK@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGK@ protein between cysteines 43 and 109 (23 and 88 respectively in this structure).

Details

Redox score ?
74
PDB code
6udk
Structure name
hiv-1 bnab 1-55 in complex with modified bg505 sosip-based immunogen rc1 and 10-1074
Structure deposition date
2019-09-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
8
% buried
77
Peptide accession
Q6PJF2
Residue number A
43
Residue number B
109
Peptide name
IGK@ protein

Ligandability

Cysteine 43 of IGK@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of IGK@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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