ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig-like domain-containing protein

Intramolecular
Cysteine 41 and cysteine 109
Cysteine 157 and cysteine 216
A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 41 and 109 (22 and 90 respectively in this structure).

Details

Redox score ?
81
PDB code
1jvk
Structure name
three-dimensional structure of an immunoglobulin light chain dimer acting as a lethal amyloid precursor
Structure deposition date
2001-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PJG0
Residue number A
41
Residue number B
109
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 41 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 157 and 216 (139 and 198 respectively in this structure).

Details

Redox score ?
78
PDB code
1jvk
Structure name
three-dimensional structure of an immunoglobulin light chain dimer acting as a lethal amyloid precursor
Structure deposition date
2001-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PJG0
Residue number A
157
Residue number B
216
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 157 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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