Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Intramolecular
Cysteine 17 and cysteine 23
Cysteine 240 and cysteine 278
Cysteine 21 and cysteine 34
Cysteine 238 and cysteine 257
Cysteine 17 and cysteine 21
Cysteine 21 and cysteine 23
Cysteine 17 and cysteine 34
Cysteine 23 and cysteine 34
6tl8 D 17 D 23
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 4 between cysteines 17 and 23.
Details
Redox score ?
87
PDB code
6tl8
Structure name
structural basis of salm3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases
Structure deposition date
2019-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80XU8
Residue number A
17
Residue number B
23
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Ligandability
Cysteine 17 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Cysteine 23 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
6tl8 C 240 C 278
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 4 between cysteines 240 and 278.
Details
Redox score ?
87
PDB code
6tl8
Structure name
structural basis of salm3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases
Structure deposition date
2019-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80XU8
Residue number A
240
Residue number B
278
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Ligandability
Cysteine 240 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Cysteine 278 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
6tl8 B 21 B 34
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 4 between cysteines 21 and 34.
Details
Redox score ?
86
PDB code
6tl8
Structure name
structural basis of salm3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases
Structure deposition date
2019-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80XU8
Residue number A
21
Residue number B
34
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Ligandability
Cysteine 21 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Cysteine 34 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
6tl8 C 238 C 257
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 4 between cysteines 238 and 257.
Details
Redox score ?
82
PDB code
6tl8
Structure name
structural basis of salm3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases
Structure deposition date
2019-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80XU8
Residue number A
238
Residue number B
257
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Ligandability
Cysteine 238 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Cysteine 257 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
6tl8 A 17 A 21
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 4 between cysteines 17 and 21.
Details
Redox score ?
65
PDB code
6tl8
Structure name
structural basis of salm3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases
Structure deposition date
2019-12-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80XU8
Residue number A
17
Residue number B
21
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Ligandability
Cysteine 17 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Cysteine 21 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
6tl8 A 21 A 23
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 4 between cysteines 21 and 23.
Details
Redox score ?
62
PDB code
6tl8
Structure name
structural basis of salm3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases
Structure deposition date
2019-12-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80XU8
Residue number A
21
Residue number B
23
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Ligandability
Cysteine 21 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Cysteine 23 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
6tl8 D 17 D 34
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 4 between cysteines 17 and 34. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6tl8
Structure name
structural basis of salm3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases
Structure deposition date
2019-12-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80XU8
Residue number A
17
Residue number B
34
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Ligandability
Cysteine 17 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Cysteine 34 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
6tl8 A 23 A 34
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 4 between cysteines 23 and 34. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
6tl8
Structure name
structural basis of salm3 dimerization and adhesion complex formation with the presynaptic receptor protein tyrosine phosphatases
Structure deposition date
2019-12-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80XU8
Residue number A
23
Residue number B
34
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Ligandability
Cysteine 23 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
Cysteine 34 of Leucine-rich repeat and fibronectin type-III domain-containing protein 4
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