a tool for identifying drug-targetable redox-active disulphides

IGL@ protein

Intramolecular

Cysteine 61 and cysteine 120

A redox-regulated disulphide may form within IGL@ protein between cysteines 61 and 120 (138 and 197 respectively in this structure).

Details

Redox score ?

78

PDB code

Structure name

structure of redesigned igg1 first constant and lambda domains (ch1:clambda constant redesign 2 beta, crd2b) at 1

Structure deposition date

2013-07-09

Thiol separation (Å)

2

Half-sphere exposure sum ?

89

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

61

Residue number B

120

Peptide name

IGL@ protein

Ligandability

Cysteine 61 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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