ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Hepatitis B virus receptor binding protein

Intramolecular
Cysteine 162 and cysteine 222
Cysteine 268 and cysteine 326
Cysteine 45 and cysteine 101
Cysteine 268 and cysteine 45
A redox-regulated disulphide may form within Hepatitis B virus receptor binding protein between cysteines 162 and 222 (261 and 321 respectively in this structure).

Details

Redox score ?
81
PDB code
3c2s
Structure name
structural characterization of a human fc fragment engineered for lack of effector functions
Structure deposition date
2008-01-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PYX1
Residue number A
162
Residue number B
222
Peptide name
Hepatitis B virus receptor binding protein

Ligandability

Cysteine 162 of Hepatitis B virus receptor binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 222 of Hepatitis B virus receptor binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis B virus receptor binding protein between cysteines 268 and 326 (367 and 425 respectively in this structure).

Details

Redox score ?
80
PDB code
4qgt
Structure name
the crystal structure of human igg fc domain with enhanced aromatic sequon
Structure deposition date
2014-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PYX1
Residue number A
268
Residue number B
326
Peptide name
Hepatitis B virus receptor binding protein

Ligandability

Cysteine 268 of Hepatitis B virus receptor binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of Hepatitis B virus receptor binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis B virus receptor binding protein between cysteines 45 and 101 (136 and 192 respectively in this structure).

Details

Redox score ?
79
PDB code
4nhh
Structure name
structure of 2g12 igg dimer
Structure deposition date
2013-11-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PYX1
Residue number A
45
Residue number B
101
Peptide name
Hepatitis B virus receptor binding protein

Ligandability

Cysteine 45 of Hepatitis B virus receptor binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Hepatitis B virus receptor binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis B virus receptor binding protein between cysteines 268 and 45 (22 and 94 respectively in this structure).

Details

Redox score ?
79
PDB code
4nhh
Structure name
structure of 2g12 igg dimer
Structure deposition date
2013-11-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6PYX1
Residue number A
268
Residue number B
45
Peptide name
Hepatitis B virus receptor binding protein

Ligandability

Cysteine 268 of Hepatitis B virus receptor binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 45 of Hepatitis B virus receptor binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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