Epidermal growth factor
Intramolecular
Cysteine 6 and cysteine 20
Cysteine 14 and cysteine 31
Cysteine 33 and cysteine 42
Cysteine 31 and cysteine 42
Cysteine 14 and cysteine 20
Cysteine 14 and cysteine 42
Cysteine 31 and cysteine 33
Cysteine 20 and cysteine 31
Cysteine 6 and cysteine 14
Cysteine 14 and cysteine 33
More...Cysteine 6 and cysteine 31
Cysteine 20 and cysteine 42
Cysteine 20 and cysteine 33
3njp D 6 D 20
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 6 and 20.
Details
Redox score ?
87
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
6
Residue number B
20
Peptide name
Epidermal growth factor
Ligandability
Cysteine 6 of Epidermal growth factor
Cysteine 20 of Epidermal growth factor
3njp D 14 D 31
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 14 and 31.
Details
Redox score ?
84
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
14
Residue number B
31
Peptide name
Epidermal growth factor
Ligandability
Cysteine 14 of Epidermal growth factor
Cysteine 31 of Epidermal growth factor
3njp C 33 C 42
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 33 and 42.
Details
Redox score ?
83
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
33
Residue number B
42
Peptide name
Epidermal growth factor
Ligandability
Cysteine 33 of Epidermal growth factor
Cysteine 42 of Epidermal growth factor
3njp D 31 D 42
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 31 and 42.
Details
Redox score ?
68
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
31
Residue number B
42
Peptide name
Epidermal growth factor
Ligandability
Cysteine 31 of Epidermal growth factor
Cysteine 42 of Epidermal growth factor
3njp C 14 C 20
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 14 and 20.
Details
Redox score ?
68
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
14
Residue number B
20
Peptide name
Epidermal growth factor
Ligandability
Cysteine 14 of Epidermal growth factor
Cysteine 20 of Epidermal growth factor
3njp C 14 C 42
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 14 and 42.
Details
Redox score ?
66
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
14
Residue number B
42
Peptide name
Epidermal growth factor
Ligandability
Cysteine 14 of Epidermal growth factor
Cysteine 42 of Epidermal growth factor
3njp C 31 C 33
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 31 and 33.
Details
Redox score ?
62
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
31
Residue number B
33
Peptide name
Epidermal growth factor
Ligandability
Cysteine 31 of Epidermal growth factor
Cysteine 33 of Epidermal growth factor
3njp C 20 C 31
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 20 and 31.
Details
Redox score ?
62
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
20
Residue number B
31
Peptide name
Epidermal growth factor
Ligandability
Cysteine 20 of Epidermal growth factor
Cysteine 31 of Epidermal growth factor
3njp C 6 C 14
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 6 and 14.
Details
Redox score ?
61
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
6
Residue number B
14
Peptide name
Epidermal growth factor
Ligandability
Cysteine 6 of Epidermal growth factor
Cysteine 14 of Epidermal growth factor
3njp C 14 C 33
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 14 and 33. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
14
Residue number B
33
Peptide name
Epidermal growth factor
Ligandability
Cysteine 14 of Epidermal growth factor
Cysteine 33 of Epidermal growth factor
3njp D 6 D 31
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 6 and 31. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
6
Residue number B
31
Peptide name
Epidermal growth factor
Ligandability
Cysteine 6 of Epidermal growth factor
Cysteine 31 of Epidermal growth factor
3njp D 20 D 42
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 20 and 42. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
3njp
Structure name
the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
Structure deposition date
2010-06-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
20
Residue number B
42
Peptide name
Epidermal growth factor
Ligandability
Cysteine 20 of Epidermal growth factor
Cysteine 42 of Epidermal growth factor
2kv4 A 20 A 33
A redox-regulated disulphide may form within Epidermal growth factor between cysteines 20 and 33. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
2kv4
Structure name
egf
Structure deposition date
2010-03-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QBS2
Residue number A
20
Residue number B
33
Peptide name
Epidermal growth factor
Ligandability
Cysteine 20 of Epidermal growth factor
Cysteine 33 of Epidermal growth factor
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