ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Intramolecular
Cysteine 185 and cysteine 186
Cysteine 186 and cysteine 373
A redox-regulated disulphide may form within Peroxisomal N(1)-acetyl-spermine/spermidine oxidase between cysteines 185 and 186. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5mbx
Structure name
crystal structure of reduced murine n1-acetylpolyamine oxidase in complex with n1-acetylspermine
Structure deposition date
2016-11-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
100
Peptide accession
Q8C0L6
Residue number A
185
Residue number B
186
Peptide name
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Ligandability

Cysteine 185 of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peroxisomal N(1)-acetyl-spermine/spermidine oxidase between cysteines 186 and 373. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
5lae
Structure name
crystal structure of murine n1-acetylpolyamine oxidase
Structure deposition date
2016-06-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
100
Peptide accession
Q8C0L6
Residue number A
186
Residue number B
373
Peptide name
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Ligandability

Cysteine 186 of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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