ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Adhesion G-protein coupled receptor D1

Intramolecular
Cysteine 632 and cysteine 704
Cysteine 580 and cysteine 807
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor D1 between cysteines 632 and 704.

Details

Redox score ?
84
PDB code
7ept
Structure name
structural basis for the tethered peptide activation of adhesion gpcrs
Structure deposition date
2021-04-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6QNK2
Residue number A
632
Residue number B
704
Peptide name
Adhesion G-protein coupled receptor D1

Ligandability

Cysteine 632 of Adhesion G-protein coupled receptor D1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 704 of Adhesion G-protein coupled receptor D1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adhesion G-protein coupled receptor D1 between cysteines 580 and 807. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7wu2
Structure name
cryo-em structure of the adhesion gpcr adgrd1 in complex with minigs
Structure deposition date
2022-02-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
48
Peptide accession
Q6QNK2
Residue number A
580
Residue number B
807
Peptide name
Adhesion G-protein coupled receptor D1

Ligandability

Cysteine 580 of Adhesion G-protein coupled receptor D1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 807 of Adhesion G-protein coupled receptor D1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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