a tool for identifying drug-targetable redox-active disulphides

Interleukin-2

Intramolecular

Cysteine 58 and cysteine 105

A redox-regulated disulphide may form within Interleukin-2 between cysteines 58 and 105.

Details

Redox score ?

86

PDB code

Structure name

small molecular fragment bound to crystal contact interface of interleukin-2

Structure deposition date

2013-10-29

Thiol separation (Å)

2

Half-sphere exposure sum ?

55

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

58

Residue number B

105

Peptide name

Interleukin-2

Ligandability

Cysteine 58 of Interleukin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Interleukin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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