ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Baculoviral IAP repeat-containing 7

Intramolecular
Cysteine 127 and cysteine 151
Cysteine 124 and cysteine 151
Cysteine 124 and cysteine 127
A redox-regulated disulphide may form within Baculoviral IAP repeat-containing 7 between cysteines 127 and 151. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
3gta
Structure name
structure of an ml-iap/xiap chimera bound to a peptidomimetic
Structure deposition date
2009-03-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
18
% buried
nan
Peptide accession
Q6R308
Residue number A
127
Residue number B
151
Peptide name
Baculoviral IAP repeat-containing 7

Ligandability

Cysteine 127 of Baculoviral IAP repeat-containing 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Baculoviral IAP repeat-containing 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Baculoviral IAP repeat-containing 7 between cysteines 124 and 151. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
3gt9
Structure name
structure of an ml-iap/xiap chimera bound to a peptidomimetic
Structure deposition date
2009-03-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
18
% buried
nan
Peptide accession
Q6R308
Residue number A
124
Residue number B
151
Peptide name
Baculoviral IAP repeat-containing 7

Ligandability

Cysteine 124 of Baculoviral IAP repeat-containing 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Baculoviral IAP repeat-containing 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Baculoviral IAP repeat-containing 7 between cysteines 124 and 127. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3f7i
Structure name
structure of an ml-iap/xiap chimera bound to a peptidomimetic
Structure deposition date
2008-11-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
18
% buried
nan
Peptide accession
Q6R308
Residue number A
124
Residue number B
127
Peptide name
Baculoviral IAP repeat-containing 7

Ligandability

Cysteine 124 of Baculoviral IAP repeat-containing 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Baculoviral IAP repeat-containing 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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