ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class I heavy chain maturation peptide H-2K(D)

Intramolecular
Cysteine 102 and cysteine 165
Cysteine 204 and cysteine 260
A redox-regulated disulphide may form within MHC class I heavy chain maturation peptide H-2K(D) between cysteines 102 and 165 (101 and 164 respectively in this structure).

Details

Redox score ?
82
PDB code
8d5j
Structure name
the complex of pre-mrna-processing factor 19 (prpf19) neoantigen kylqvashv presented by h2-kd
Structure deposition date
2022-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6RJ37
Residue number A
102
Residue number B
165
Peptide name
MHC class I heavy chain maturation peptide H-2K(D)

Ligandability

Cysteine 102 of MHC class I heavy chain maturation peptide H-2K(D)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of MHC class I heavy chain maturation peptide H-2K(D)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I heavy chain maturation peptide H-2K(D) between cysteines 204 and 260 (203 and 259 respectively in this structure).

Details

Redox score ?
80
PDB code
8d5j
Structure name
the complex of pre-mrna-processing factor 19 (prpf19) neoantigen kylqvashv presented by h2-kd
Structure deposition date
2022-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6RJ37
Residue number A
204
Residue number B
260
Peptide name
MHC class I heavy chain maturation peptide H-2K(D)

Ligandability

Cysteine 204 of MHC class I heavy chain maturation peptide H-2K(D)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of MHC class I heavy chain maturation peptide H-2K(D)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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