ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kelch-like protein 17

Intramolecular
Cysteine 428 and cysteine 449
A redox-regulated disulphide may form within Kelch-like protein 17 between cysteines 428 and 449 (426 and 447 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6hrl
Structure name
crystal structure of the kelch domain of human klhl17
Structure deposition date
2018-09-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
73
Peptide accession
Q6TDP4
Residue number A
428
Residue number B
449
Peptide name
Kelch-like protein 17

Ligandability

Cysteine 428 of Kelch-like protein 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 449 of Kelch-like protein 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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