Epigen
Intramolecular
Cysteine 60 and cysteine 73
Cysteine 68 and cysteine 84
Cysteine 86 and cysteine 95
Cysteine 84 and cysteine 95
Cysteine 84 and cysteine 86
Cysteine 68 and cysteine 95
Cysteine 60 and cysteine 68
Cysteine 68 and cysteine 86
Cysteine 68 and cysteine 73
Cysteine 60 and cysteine 84
More...Cysteine 73 and cysteine 84
Cysteine 73 and cysteine 95
5wb8 B 38 B 51
A redox-regulated disulphide may form within Epigen between cysteines 60 and 73 (38 and 51 respectively in this structure).
Details
Redox score ?
89
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
60
Residue number B
73
Peptide name
Epigen
Ligandability
Cysteine 60 of Epigen
Cysteine 73 of Epigen
5wb8 B 46 B 62
A redox-regulated disulphide may form within Epigen between cysteines 68 and 84 (46 and 62 respectively in this structure).
Details
Redox score ?
84
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
68
Residue number B
84
Peptide name
Epigen
Ligandability
Cysteine 68 of Epigen
Cysteine 84 of Epigen
5wb8 C 64 C 73
A redox-regulated disulphide may form within Epigen between cysteines 86 and 95 (64 and 73 respectively in this structure).
Details
Redox score ?
83
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
86
Residue number B
95
Peptide name
Epigen
Ligandability
Cysteine 86 of Epigen
Cysteine 95 of Epigen
5wb8 B 62 B 73
A redox-regulated disulphide may form within Epigen between cysteines 84 and 95 (62 and 73 respectively in this structure).
Details
Redox score ?
71
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
84
Residue number B
95
Peptide name
Epigen
Ligandability
Cysteine 84 of Epigen
Cysteine 95 of Epigen
5wb8 B 62 B 64
A redox-regulated disulphide may form within Epigen between cysteines 84 and 86 (62 and 64 respectively in this structure).
Details
Redox score ?
66
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
84
Residue number B
86
Peptide name
Epigen
Ligandability
Cysteine 84 of Epigen
Cysteine 86 of Epigen
5wb8 C 46 C 73
A redox-regulated disulphide may form within Epigen between cysteines 68 and 95 (46 and 73 respectively in this structure).
Details
Redox score ?
66
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
68
Residue number B
95
Peptide name
Epigen
Ligandability
Cysteine 68 of Epigen
Cysteine 95 of Epigen
5wb8 B 38 B 46
A redox-regulated disulphide may form within Epigen between cysteines 60 and 68 (38 and 46 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
60
Residue number B
68
Peptide name
Epigen
Ligandability
Cysteine 60 of Epigen
Cysteine 68 of Epigen
5wb8 B 46 B 64
A redox-regulated disulphide may form within Epigen between cysteines 68 and 86 (46 and 64 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
68
Residue number B
86
Peptide name
Epigen
Ligandability
Cysteine 68 of Epigen
Cysteine 86 of Epigen
5wb8 B 46 B 51
A redox-regulated disulphide may form within Epigen between cysteines 68 and 73 (46 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
68
Residue number B
73
Peptide name
Epigen
Ligandability
Cysteine 68 of Epigen
Cysteine 73 of Epigen
5wb8 B 38 B 62
A redox-regulated disulphide may form within Epigen between cysteines 60 and 84 (38 and 62 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
60
Residue number B
84
Peptide name
Epigen
Ligandability
Cysteine 60 of Epigen
Cysteine 84 of Epigen
5wb8 B 51 B 62
A redox-regulated disulphide may form within Epigen between cysteines 73 and 84 (51 and 62 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UW88
Residue number A
73
Residue number B
84
Peptide name
Epigen
Ligandability
Cysteine 73 of Epigen
Cysteine 84 of Epigen
5wb8 C 51 C 73
A redox-regulated disulphide may form within Epigen between cysteines 73 and 95 (51 and 73 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
5wb8
Structure name
crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Structure deposition date
2017-06-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
nan
Peptide accession
Q6UW88
Residue number A
73
Residue number B
95
Peptide name
Epigen
Ligandability
Cysteine 73 of Epigen
Cysteine 95 of Epigen
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