ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-27 receptor subunit alpha

Intramolecular
Cysteine 41 and cysteine 52
Cysteine 164 and cysteine 208
A redox-regulated disulphide may form within Interleukin-27 receptor subunit alpha between cysteines 41 and 52.

Details

Redox score ?
84
PDB code
7u7n
Structure name
il-27 quaternary receptor signaling complex
Structure deposition date
2022-03-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UWB1
Residue number A
41
Residue number B
52
Peptide name
Interleukin-27 receptor subunit alpha

Ligandability

Cysteine 41 of Interleukin-27 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Interleukin-27 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-27 receptor subunit alpha between cysteines 164 and 208.

Details

Redox score ?
82
PDB code
7u7n
Structure name
il-27 quaternary receptor signaling complex
Structure deposition date
2022-03-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UWB1
Residue number A
164
Residue number B
208
Peptide name
Interleukin-27 receptor subunit alpha

Ligandability

Cysteine 164 of Interleukin-27 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Interleukin-27 receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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