Serine protease inhibitor Kazal-type 6
Intramolecular
Cysteine 48 and cysteine 80
Cysteine 40 and cysteine 59
Cysteine 30 and cysteine 62
Cysteine 30 and cysteine 40
Cysteine 30 and cysteine 59
Cysteine 59 and cysteine 62
Cysteine 40 and cysteine 62
2n52 A 25 A 57
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 6 between cysteines 48 and 80 (25 and 57 respectively in this structure).
Details
Redox score ?
87
PDB code
2n52
Structure name
the solution structure of the kallikrein inhibitor spink6
Structure deposition date
2015-07-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UWN8
Residue number A
48
Residue number B
80
Peptide name
Serine protease inhibitor Kazal-type 6
Ligandability
Cysteine 48 of Serine protease inhibitor Kazal-type 6
Cysteine 80 of Serine protease inhibitor Kazal-type 6
1bus A 17 A 36
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 6 between cysteines 40 and 59 (17 and 36 respectively in this structure).
Details
Redox score ?
84
PDB code
1bus
Structure name
solution conformation of proteinase inhibitor iia from bull seminal plasma by 1h nuclear magnetic resonance and distance geometry
Structure deposition date
1990-05-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01001
Residue number A
40
Residue number B
59
Peptide name
Serine protease inhibitor Kazal-type 6
Ligandability
Cysteine 40 of Serine protease inhibitor Kazal-type 6
Cysteine 59 of Serine protease inhibitor Kazal-type 6
2n52 A 7 A 39
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 6 between cysteines 30 and 62 (7 and 39 respectively in this structure).
Details
Redox score ?
82
PDB code
2n52
Structure name
the solution structure of the kallikrein inhibitor spink6
Structure deposition date
2015-07-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UWN8
Residue number A
30
Residue number B
62
Peptide name
Serine protease inhibitor Kazal-type 6
Ligandability
Cysteine 30 of Serine protease inhibitor Kazal-type 6
Cysteine 62 of Serine protease inhibitor Kazal-type 6
2n52 A 7 A 17
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 6 between cysteines 30 and 40 (7 and 17 respectively in this structure).
Details
Redox score ?
76
PDB code
2n52
Structure name
the solution structure of the kallikrein inhibitor spink6
Structure deposition date
2015-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UWN8
Residue number A
30
Residue number B
40
Peptide name
Serine protease inhibitor Kazal-type 6
Ligandability
Cysteine 30 of Serine protease inhibitor Kazal-type 6
Cysteine 40 of Serine protease inhibitor Kazal-type 6
2n52 A 7 A 36
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 6 between cysteines 30 and 59 (7 and 36 respectively in this structure).
Details
Redox score ?
70
PDB code
2n52
Structure name
the solution structure of the kallikrein inhibitor spink6
Structure deposition date
2015-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UWN8
Residue number A
30
Residue number B
59
Peptide name
Serine protease inhibitor Kazal-type 6
Ligandability
Cysteine 30 of Serine protease inhibitor Kazal-type 6
Cysteine 59 of Serine protease inhibitor Kazal-type 6
2n52 A 36 A 39
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 6 between cysteines 59 and 62 (36 and 39 respectively in this structure).
Details
Redox score ?
63
PDB code
2n52
Structure name
the solution structure of the kallikrein inhibitor spink6
Structure deposition date
2015-07-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UWN8
Residue number A
59
Residue number B
62
Peptide name
Serine protease inhibitor Kazal-type 6
Ligandability
Cysteine 59 of Serine protease inhibitor Kazal-type 6
Cysteine 62 of Serine protease inhibitor Kazal-type 6
1bus A 17 A 39
A redox-regulated disulphide may form within Serine protease inhibitor Kazal-type 6 between cysteines 40 and 62 (17 and 39 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
1bus
Structure name
solution conformation of proteinase inhibitor iia from bull seminal plasma by 1h nuclear magnetic resonance and distance geometry
Structure deposition date
1990-05-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01001
Residue number A
40
Residue number B
62
Peptide name
Serine protease inhibitor Kazal-type 6
Ligandability
Cysteine 40 of Serine protease inhibitor Kazal-type 6
Cysteine 62 of Serine protease inhibitor Kazal-type 6
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