a tool for identifying drug-targetable redox-active disulphides

Spliceosome-associated protein CWC27 homolog

Intramolecular

Cysteine 44 and cysteine 164

A redox-regulated disulphide may form within Spliceosome-associated protein CWC27 homolog between cysteines 44 and 164.

Details

Redox score ?

74

PDB code

Structure name

structure of the spliceosomal peptidyl-prolyl cis-trans isomerase cwc27 from homo sapiens

Structure deposition date

2014-08-15

Thiol separation (Å)

4

Half-sphere exposure sum ?

68

Minimum pK_a ?

9

% buried

90

Peptide accession

Residue number A

44

Residue number B

164

Peptide name

Spliceosome-associated protein CWC27 homolog

Ligandability

Cysteine 44 of Spliceosome-associated protein CWC27 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Spliceosome-associated protein CWC27 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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