a tool for identifying drug-targetable redox-active disulphides

Leucine-rich repeats and immunoglobulin-like domains protein 3

Intramolecular

Cysteine 520 and cysteine 581

A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 3 between cysteines 520 and 581.

Details

Redox score ?

68

PDB code

Structure name

crystal structure of an immunoglobulin i-set domain of lrig3 protein (lrig3) from mus musculus at 1

Structure deposition date

2011-06-29

Thiol separation (Å)

4

Half-sphere exposure sum ?

77

Minimum pK_a ?

9

% buried

91

Peptide accession

Residue number A

520

Residue number B

581

Peptide name

Leucine-rich repeats and immunoglobulin-like domains protein 3

Ligandability

Cysteine 520 of Leucine-rich repeats and immunoglobulin-like domains protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 581 of Leucine-rich repeats and immunoglobulin-like domains protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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