ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ALK and LTK ligand 1

Intramolecular
Cysteine 90 and cysteine 126
Cysteine 104 and cysteine 113
A redox-regulated disulphide may form within ALK and LTK ligand 1 between cysteines 90 and 126.

Details

Redox score ?
90
PDB code
7nx0
Structure name
ltk:alkal1 complex stabilized by a nanobody
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXT8
Residue number A
90
Residue number B
126
Peptide name
ALK and LTK ligand 1

Ligandability

Cysteine 90 of ALK and LTK ligand 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of ALK and LTK ligand 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ALK and LTK ligand 1 between cysteines 104 and 113.

Details

Redox score ?
83
PDB code
7nx0
Structure name
ltk:alkal1 complex stabilized by a nanobody
Structure deposition date
2021-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXT8
Residue number A
104
Residue number B
113
Peptide name
ALK and LTK ligand 1

Ligandability

Cysteine 104 of ALK and LTK ligand 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of ALK and LTK ligand 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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