ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GDNF family receptor alpha-like

Intramolecular
Cysteine 227 and cysteine 233
Cysteine 269 and cysteine 316
Cysteine 252 and cysteine 258
Cysteine 162 and cysteine 210
Cysteine 191 and cysteine 198
Cysteine 244 and cysteine 275
Cysteine 131 and cysteine 189
Cysteine 293 and cysteine 304
Cysteine 138 and cysteine 144
Cysteine 155 and cysteine 167
More...
Cysteine 220 and cysteine 291
Cysteine 269 and cysteine 275
Cysteine 275 and cysteine 316
Cysteine 167 and cysteine 210
Cysteine 131 and cysteine 191
Cysteine 244 and cysteine 316
Cysteine 244 and cysteine 269
Cysteine 220 and cysteine 304
Cysteine 220 and cysteine 293
Cysteine 131 and cysteine 198
Cysteine 162 and cysteine 167
Cysteine 155 and cysteine 210
Cysteine 189 and cysteine 191
Cysteine 291 and cysteine 293
Cysteine 291 and cysteine 304
Cysteine 155 and cysteine 162
Cysteine 189 and cysteine 198
A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 227 and 233.

Details

Redox score ?
88
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
227
Residue number B
233
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 227 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 269 and 316.

Details

Redox score ?
87
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
269
Residue number B
316
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 269 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 252 and 258.

Details

Redox score ?
86
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
252
Residue number B
258
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 252 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 162 and 210.

Details

Redox score ?
85
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
162
Residue number B
210
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 162 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 191 and 198.

Details

Redox score ?
85
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
191
Residue number B
198
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 191 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 244 and 275.

Details

Redox score ?
85
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
244
Residue number B
275
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 244 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 131 and 189.

Details

Redox score ?
84
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
131
Residue number B
189
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 131 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 293 and 304.

Details

Redox score ?
84
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
293
Residue number B
304
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 293 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 138 and 144.

Details

Redox score ?
83
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
138
Residue number B
144
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 138 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 155 and 167.

Details

Redox score ?
82
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
155
Residue number B
167
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 155 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 220 and 291.

Details

Redox score ?
82
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
220
Residue number B
291
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 220 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 269 and 275.

Details

Redox score ?
77
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
269
Residue number B
275
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 269 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 275 and 316.

Details

Redox score ?
75
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
275
Residue number B
316
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 275 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 167 and 210.

Details

Redox score ?
73
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
167
Residue number B
210
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 167 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 131 and 191.

Details

Redox score ?
72
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
131
Residue number B
191
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 131 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 244 and 316.

Details

Redox score ?
70
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
244
Residue number B
316
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 244 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 244 and 269.

Details

Redox score ?
70
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
244
Residue number B
269
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 244 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 220 and 304.

Details

Redox score ?
69
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
220
Residue number B
304
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 220 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 220 and 293.

Details

Redox score ?
67
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
220
Residue number B
293
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 220 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 131 and 198.

Details

Redox score ?
66
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
131
Residue number B
198
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 131 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 162 and 167.

Details

Redox score ?
66
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
162
Residue number B
167
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 162 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 155 and 210.

Details

Redox score ?
65
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
155
Residue number B
210
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 155 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 189 and 191.

Details

Redox score ?
64
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
189
Residue number B
191
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 189 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 291 and 293.

Details

Redox score ?
63
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
291
Residue number B
293
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 291 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 291 and 304. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
291
Residue number B
304
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 291 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 155 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
155
Residue number B
162
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 155 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-like between cysteines 189 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6wmw
Structure name
gfral receptor bound with two antibody fabs (3p10, 25m22)
Structure deposition date
2020-04-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6UXV0
Residue number A
189
Residue number B
198
Peptide name
GDNF family receptor alpha-like

Ligandability

Cysteine 189 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of GDNF family receptor alpha-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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