ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Netrin receptor UNC5D

Intramolecular
Cysteine 266 and cysteine 303
Cysteine 262 and cysteine 299
Cysteine 277 and cysteine 289
Cysteine 178 and cysteine 229
Cysteine 85 and cysteine 132
Cysteine 73 and cysteine 134
Cysteine 85 and cysteine 134
Cysteine 299 and cysteine 303
Cysteine 132 and cysteine 134
A redox-regulated disulphide may form within Netrin receptor UNC5D between cysteines 266 and 303.

Details

Redox score ?
90
PDB code
5ftt
Structure name
octameric complex of latrophilin 3 (lec, olf) , unc5d (ig, ig2, tsp1) and flrt2 (lrr)
Structure deposition date
2016-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
F1LW30
Residue number A
266
Residue number B
303
Peptide name
Netrin receptor UNC5D

Ligandability

Cysteine 266 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 303 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5D between cysteines 262 and 299.

Details

Redox score ?
87
PDB code
5ftt
Structure name
octameric complex of latrophilin 3 (lec, olf) , unc5d (ig, ig2, tsp1) and flrt2 (lrr)
Structure deposition date
2016-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
F1LW30
Residue number A
262
Residue number B
299
Peptide name
Netrin receptor UNC5D

Ligandability

Cysteine 262 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5D between cysteines 277 and 289.

Details

Redox score ?
86
PDB code
5ftt
Structure name
octameric complex of latrophilin 3 (lec, olf) , unc5d (ig, ig2, tsp1) and flrt2 (lrr)
Structure deposition date
2016-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
F1LW30
Residue number A
277
Residue number B
289
Peptide name
Netrin receptor UNC5D

Ligandability

Cysteine 277 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 289 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5D between cysteines 178 and 229.

Details

Redox score ?
82
PDB code
5ftt
Structure name
octameric complex of latrophilin 3 (lec, olf) , unc5d (ig, ig2, tsp1) and flrt2 (lrr)
Structure deposition date
2016-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
F1LW30
Residue number A
178
Residue number B
229
Peptide name
Netrin receptor UNC5D

Ligandability

Cysteine 178 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5D between cysteines 85 and 132.

Details

Redox score ?
77
PDB code
5ftu
Structure name
tetrameric complex of latrophilin 3, unc5d and flrt2
Structure deposition date
2016-01-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
75
Peptide accession
F1LW30
Residue number A
85
Residue number B
132
Peptide name
Netrin receptor UNC5D

Ligandability

Cysteine 85 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5D between cysteines 73 and 134.

Details

Redox score ?
73
PDB code
5ftu
Structure name
tetrameric complex of latrophilin 3, unc5d and flrt2
Structure deposition date
2016-01-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
8
% buried
92
Peptide accession
F1LW30
Residue number A
73
Residue number B
134
Peptide name
Netrin receptor UNC5D

Ligandability

Cysteine 73 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5D between cysteines 85 and 134. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5ftu
Structure name
tetrameric complex of latrophilin 3, unc5d and flrt2
Structure deposition date
2016-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
91
Peptide accession
F1LW30
Residue number A
85
Residue number B
134
Peptide name
Netrin receptor UNC5D

Ligandability

Cysteine 85 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5D between cysteines 299 and 303. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5ftt
Structure name
octameric complex of latrophilin 3 (lec, olf) , unc5d (ig, ig2, tsp1) and flrt2 (lrr)
Structure deposition date
2016-01-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
F1LW30
Residue number A
299
Residue number B
303
Peptide name
Netrin receptor UNC5D

Ligandability

Cysteine 299 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 303 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5D between cysteines 132 and 134. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5ftt
Structure name
octameric complex of latrophilin 3 (lec, olf) , unc5d (ig, ig2, tsp1) and flrt2 (lrr)
Structure deposition date
2016-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
F1LW30
Residue number A
132
Residue number B
134
Peptide name
Netrin receptor UNC5D

Ligandability

Cysteine 132 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Netrin receptor UNC5D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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