ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dipeptidyl peptidase 8

Intramolecular
Cysteine 221 and cysteine 286
Cysteine 575 and cysteine 576
A redox-regulated disulphide may form within Dipeptidyl peptidase 8 between cysteines 221 and 286. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6qzw
Structure name
dpp8 bound to a dipeptide (mp) from the n-terminus of brca2
Structure deposition date
2019-03-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
85
Peptide accession
Q6V1X1
Residue number A
221
Residue number B
286
Peptide name
Dipeptidyl peptidase 8

Ligandability

Cysteine 221 of Dipeptidyl peptidase 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of Dipeptidyl peptidase 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl peptidase 8 between cysteines 575 and 576. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6eot
Structure name
dpp8 - slrflyeg, space group 19
Structure deposition date
2017-10-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide accession
Q6V1X1
Residue number A
575
Residue number B
576
Peptide name
Dipeptidyl peptidase 8

Ligandability

Cysteine 575 of Dipeptidyl peptidase 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 576 of Dipeptidyl peptidase 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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