ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Scavenger receptor class A member 5

Intramolecular
Cysteine 462 and cysteine 472
Cysteine 431 and cysteine 492
Cysteine 414 and cysteine 478
A redox-regulated disulphide may form within Scavenger receptor class A member 5 between cysteines 462 and 472.

Details

Redox score ?
89
PDB code
7c00
Structure name
crystal structure of the srcr domain of human scara5
Structure deposition date
2020-04-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZMJ2
Residue number A
462
Residue number B
472
Peptide name
Scavenger receptor class A member 5

Ligandability

Cysteine 462 of Scavenger receptor class A member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Scavenger receptor class A member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Scavenger receptor class A member 5 between cysteines 431 and 492.

Details

Redox score ?
83
PDB code
7c00
Structure name
crystal structure of the srcr domain of human scara5
Structure deposition date
2020-04-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZMJ2
Residue number A
431
Residue number B
492
Peptide name
Scavenger receptor class A member 5

Ligandability

Cysteine 431 of Scavenger receptor class A member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 492 of Scavenger receptor class A member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Scavenger receptor class A member 5 between cysteines 414 and 478.

Details

Redox score ?
83
PDB code
7bzz
Structure name
crystal structure of the srcr domain of mouse scara5
Structure deposition date
2020-04-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K299
Residue number A
414
Residue number B
478
Peptide name
Scavenger receptor class A member 5

Ligandability

Cysteine 414 of Scavenger receptor class A member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of Scavenger receptor class A member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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