ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger protein AEBP2

Intramolecular
Cysteine 297 and cysteine 302
A redox-regulated disulphide may form within Zinc finger protein AEBP2 between cysteines 297 and 302 (89 and 94 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6wkr
Structure name
prc2-aebp2-jarid2 bound to h2ak119ub1 nucleosome
Structure deposition date
2020-04-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
24
Peptide accession
Q6ZN18
Residue number A
297
Residue number B
302
Peptide name
Zinc finger protein AEBP2

Ligandability

Cysteine 297 of Zinc finger protein AEBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 302 of Zinc finger protein AEBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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