ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Netrin receptor UNC5A

Intramolecular
Cysteine 254 and cysteine 288
Cysteine 258 and cysteine 842
Cysteine 266 and cysteine 278
Cysteine 77 and cysteine 124
Cysteine 170 and cysteine 221
Cysteine 65 and cysteine 126
Cysteine 258 and cysteine 288
Cysteine 288 and cysteine 842
Cysteine 254 and cysteine 842
Cysteine 254 and cysteine 258
More...
Cysteine 77 and cysteine 126
Cysteine 124 and cysteine 126
A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 254 and 288.

Details

Redox score ?
91
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
254
Residue number B
288
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 254 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 288 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 258 and 842 (258 and 293 respectively in this structure).

Details

Redox score ?
90
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
258
Residue number B
842
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 258 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 842 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 266 and 278.

Details

Redox score ?
88
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
266
Residue number B
278
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 266 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 77 and 124.

Details

Redox score ?
85
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
77
Residue number B
124
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 77 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 170 and 221.

Details

Redox score ?
84
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
170
Residue number B
221
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 170 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 65 and 126.

Details

Redox score ?
82
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
65
Residue number B
126
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 65 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 258 and 288.

Details

Redox score ?
74
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
258
Residue number B
288
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 258 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 288 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 288 and 842 (288 and 293 respectively in this structure).

Details

Redox score ?
73
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
288
Residue number B
842
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 288 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 842 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 254 and 842 (254 and 293 respectively in this structure).

Details

Redox score ?
66
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
254
Residue number B
842
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 254 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 842 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 254 and 258.

Details

Redox score ?
64
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
32
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
254
Residue number B
258
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 254 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 77 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
77
Residue number B
126
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 77 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor UNC5A between cysteines 124 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4v2a
Structure name
human unc5a ectodomain
Structure deposition date
2014-10-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ZN44
Residue number A
124
Residue number B
126
Peptide name
Netrin receptor UNC5A

Ligandability

Cysteine 124 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Netrin receptor UNC5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: