ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Phosphoinositide 3-kinase adapter protein 1

Intermolecular
Cysteine 284 and cysteine 284
Intramolecular
Cysteine 103 and cysteine 126
Cysteine 10 and cysteine 66
Cysteine 24 and cysteine 103
A redox-regulated disulphide may form between two units of Phosphoinositide 3-kinase adapter protein 1 at cysteines 284 and 284 (109 and 109 respectively in this structure).

Details

Redox score ?
64
PDB code
6sws
Structure name
the dbb dimerization domain of b-cell adaptor for pi3k (bcap) is required for down regulation of inflammatory signalling through the toll-like receptor pathway
Structure deposition date
2019-09-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide A name
Phosphoinositide 3-kinase adapter protein 1
Peptide B name
Phosphoinositide 3-kinase adapter protein 1
Peptide A accession
Q6ZUJ8
Peptide B accession
Q6ZUJ8
Peptide A residue number
284
Peptide B residue number
284

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphoinositide 3-kinase adapter protein 1 between cysteines 103 and 126 (100 and 123 respectively in this structure).

Details

Redox score ?
67
PDB code
5for
Structure name
cryptic tir
Structure deposition date
2015-11-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
41
Peptide accession
Q6ZUJ8
Residue number A
103
Residue number B
126
Peptide name
Phosphoinositide 3-kinase adapter protein 1

Ligandability

Cysteine 103 of Phosphoinositide 3-kinase adapter protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Phosphoinositide 3-kinase adapter protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphoinositide 3-kinase adapter protein 1 between cysteines 10 and 66 (7 and 63 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5for
Structure name
cryptic tir
Structure deposition date
2015-11-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
62
Peptide accession
Q6ZUJ8
Residue number A
10
Residue number B
66
Peptide name
Phosphoinositide 3-kinase adapter protein 1

Ligandability

Cysteine 10 of Phosphoinositide 3-kinase adapter protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Phosphoinositide 3-kinase adapter protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphoinositide 3-kinase adapter protein 1 between cysteines 24 and 103 (21 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
5for
Structure name
cryptic tir
Structure deposition date
2015-11-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
55
Peptide accession
Q6ZUJ8
Residue number A
24
Residue number B
103
Peptide name
Phosphoinositide 3-kinase adapter protein 1

Ligandability

Cysteine 24 of Phosphoinositide 3-kinase adapter protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Phosphoinositide 3-kinase adapter protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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