ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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PAX-interacting protein 1

Intramolecular
Cysteine 933 and cysteine 936
Cysteine 985 and cysteine 1029
Cysteine 1029 and cysteine 1036
A redox-regulated disulphide may form within PAX-interacting protein 1 between cysteines 933 and 936. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
3sqd
Structure name
crystal structure of human ptip brct5/6-gamma h2ax complex
Structure deposition date
2011-07-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
41
Minimum pKa ?
10
% buried
26
Peptide accession
Q6ZW49
Residue number A
933
Residue number B
936
Peptide name
PAX-interacting protein 1

Ligandability

Cysteine 933 of PAX-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 936 of PAX-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within PAX-interacting protein 1 between cysteines 985 and 1029. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3sqd
Structure name
crystal structure of human ptip brct5/6-gamma h2ax complex
Structure deposition date
2011-07-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
8
Peptide accession
Q6ZW49
Residue number A
985
Residue number B
1029
Peptide name
PAX-interacting protein 1

Ligandability

Cysteine 985 of PAX-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1029 of PAX-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within PAX-interacting protein 1 between cysteines 1029 and 1036. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
3sqd
Structure name
crystal structure of human ptip brct5/6-gamma h2ax complex
Structure deposition date
2011-07-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
28
Peptide accession
Q6ZW49
Residue number A
1029
Residue number B
1036
Peptide name
PAX-interacting protein 1

Ligandability

Cysteine 1029 of PAX-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1036 of PAX-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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