ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Ubiquitin carboxyl-terminal hydrolase 34

Intermolecular
Cysteine 1903 and cysteine 1903
Intramolecular
Cysteine 2018 and cysteine 2062
Cysteine 2018 and cysteine 2065
Cysteine 2062 and cysteine 2065
A redox-regulated disulphide may form between two units of Ubiquitin carboxyl-terminal hydrolase 34 at cysteines 1903 and 1903. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7w3u
Structure name
usp34 catalytic domain in complex with ubpa
Structure deposition date
2021-11-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
93
Minimum pKa ?
10
% buried
100
Peptide A name
Ubiquitin carboxyl-terminal hydrolase 34
Peptide B name
Ubiquitin carboxyl-terminal hydrolase 34
Peptide A accession
Q70CQ2
Peptide B accession
Q70CQ2
Peptide A residue number
1903
Peptide B residue number
1903

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 34 between cysteines 2018 and 2062.

Details

Redox score ?
85
PDB code
7w3u
Structure name
usp34 catalytic domain in complex with ubpa
Structure deposition date
2021-11-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
7
% buried
0
Peptide accession
Q70CQ2
Residue number A
2018
Residue number B
2062
Peptide name
Ubiquitin carboxyl-terminal hydrolase 34

Ligandability

Cysteine 2018 of Ubiquitin carboxyl-terminal hydrolase 34

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2062 of Ubiquitin carboxyl-terminal hydrolase 34

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 34 between cysteines 2018 and 2065.

Details

Redox score ?
84
PDB code
7w3r
Structure name
usp34 catalytic domain
Structure deposition date
2021-11-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
7
% buried
0
Peptide accession
Q70CQ2
Residue number A
2018
Residue number B
2065
Peptide name
Ubiquitin carboxyl-terminal hydrolase 34

Ligandability

Cysteine 2018 of Ubiquitin carboxyl-terminal hydrolase 34

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2065 of Ubiquitin carboxyl-terminal hydrolase 34

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 34 between cysteines 2062 and 2065.

Details

Redox score ?
79
PDB code
7w3u
Structure name
usp34 catalytic domain in complex with ubpa
Structure deposition date
2021-11-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide accession
Q70CQ2
Residue number A
2062
Residue number B
2065
Peptide name
Ubiquitin carboxyl-terminal hydrolase 34

Ligandability

Cysteine 2062 of Ubiquitin carboxyl-terminal hydrolase 34

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2065 of Ubiquitin carboxyl-terminal hydrolase 34

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: